Giant squid and some other large squid species maintain neutral buoyancy in seawater through an ammonium chloride solution which is found throughout their bodies and is lighter than seawater. This differs from the method of flotation used by most fish, which involves a gas-filled swim bladder. The solution tastes somewhat like salty liquorice/salmiak and makes giant squid unattractive for general human consumption.[citation needed]
https://en.wikipedia.org/wiki/Giant_squid
Most sea creatures rely on gas pockets to maintain neutral buoyancy - but this is a risky trait for deep-sea predators that risk bursting if they rise too quickly and depressurise. Instead, the giant squid circulates a high concentration of ammonium chloride solution throughout its body, which is less dense that the sodium chloride solution of seawater. This chemical tastes like salty, rotten liquorice and is the main reason nobody eats giant squids.
https://www.aquarium.co.za/news/everything-you-need-to-know-about-giant-squids
https://www.scoop.co.nz/stories/HL0805/S00013/colossal-squid-not-nearly-as-tasty-as-hoped.htm