one thing you might do is check with a recruiter or headhunter in your field and see what skills they want you to have if they are trying to sell your soul to someone. For example, in computers, one could check on dice.com and look at their "communities" - groups that combine certain skill sets that are likely employable.
Another might be on volt.com, check their office locater and have a cup of coffee with one of their recruiters, see what is selling.
If you have the capability you might want to read internationally about where it might be possible to immigrate to. The future here, at least for the next 20-30 years, with today's and the past several months jobs reports as testament, indicates that the largest numbers of jobs created will be for those who have the dexterity to cook fries faster or empty bedpans quicker, or similar low-paying positions. If you are moving here from Mexico it probably looks very good, because life there looks even worse (the CBO says the immigration bill, if passed, will increase unemployment at those levels for the next 10-15 years, btw) but if you are used to more middle class living there will be less opportunity here for at least your working lifetime.
That may not be true if you have the resources to really stand out, because there are fields where opportunity still exists, such as petroleum engineering, or working with very, very, very large databases of data about people's lives and behavior, or finance, especially where one can find a way to take what money is left out of the pockets of working people and retirement accounts, but those positions are less available than they used to be, and our population is larger.
What do you want to accomplish? As specifically as possible in an open forum...
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