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Polybius

(19,752 posts)
Mon Apr 7, 2025, 04:41 PM Apr 7

Scientists Revive the Dire Wolf, or Something Close

Source: NY Times

For more than a decade, scientists have chased the idea of reviving extinct species, a process sometimes called de-extinction. Now, a company called Colossal Biosciences appears to have done it, or something close, with the dire wolf, a giant, extinct species made famous by the television series “Game of Thrones.”

In 2021, a separate team of scientists managed to retrieve DNA from the fossils of dire wolves, which went extinct about 13,000 years ago. With the discovery of additional DNA, the Colossal researchers have now edited 20 genes of gray wolves to imbue the animals with key features of dire wolves. They then created embryos from the edited gray-wolf cells, implanted them in surrogate dog mothers and waited for them to give birth.

The result is three healthy wolves — two males that are 6 months old and one female that is 2 months old, named Romulus, Remus and Khaleesi — that have some traits of dire wolves.

They are big, for one thing, and have dense, pale coats not found in gray wolves. Colossal, which was valued at $10 billion in January, is keeping the wolves on a private 2,000-acre facility at an undisclosed location in the northern United States.

Read more: https://www.nytimes.com/2025/04/07/science/colossal-dire-wolf-deextinction.html

36 replies = new reply since forum marked as read
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Scientists Revive the Dire Wolf, or Something Close (Original Post) Polybius Apr 7 OP
NYT paywall. Here's a link to the Live Science article Wicked Blue Apr 7 #1
Thank You! nt wolfie001 Apr 7 #6
If the ranchers who hate ordinary wolves have to start Vogon_Glory Apr 7 #2
Gifted link below. herding cats Apr 7 #3
What could go wrong? Scrivener7 Apr 7 #4
$10,000,000,000 Cirsium Apr 7 #7
Jurassic Park vs Free Willy? BidenRocks Apr 8 #22
I am so out of touch Cirsium Apr 8 #33
It's always been a problem that only cute-looking adorable species get the attention needed. The twist here is that Martin68 Apr 8 #31
Sure, it starts with cute little pups, but... LudwigPastorius Apr 7 #16
That's Black Friday! nt BidenRocks Apr 8 #23
This is about science. wcollar Apr 8 #28
That was my first thought - and fear. calimary Apr 8 #18
This is good PurgedVoter Apr 7 #5
Gorgeous animal. I saw a short video of the pups. sinkingfeeling Apr 7 #8
Just because you can, doesn't mean you should. Buddyzbuddy Apr 7 #9
Unfortunately Dire "wolves" weren't wolves. Buzz cook Apr 7 #10
Dire wolves werr not enormous wolves. According to Wikipedia they about the same size as the largest modern forms Martin68 Apr 8 #32
I've seen this movie Bayard Apr 7 #11
This message was self-deleted by its author 58Sunliner Apr 7 #12
"... the dire wolf, a giant, extinct species made famous by the television series "Game of Thrones." OldBaldy1701E Apr 7 #13
Some of us were introduced to the Dire Wolf by Robert Hunter and the Gratful Dead Brother Buzz Apr 7 #17
There still working on... Xolodno Apr 7 #14
All I ask is that, if they are going to build a real life Jurassic Park,... LudwigPastorius Apr 7 #15
What, no frog DNA to fill in the gaps? generalbetrayus Apr 8 #19
They should have started with a species humans solely drove to extinction LostOne4Ever Apr 8 #20
This message was self-deleted by its author wyn borkins Apr 8 #21
The La Brea Tar Pits BidenRocks Apr 8 #24
Yeah, this comes to mind. OldBaldy1701E Apr 8 #25
Why didn't they do this for the passenger pigeon instead of the darn dire wolves? raccoon Apr 8 #26
Canid DNA has been studied a lot. Kablooie Apr 8 #35
Why not bring the dire wolf back? The Madcap Apr 8 #27
Yes, we need a major predator for our pets mdbl Apr 8 #29
Romulus and Remus are two 6-month-old dire wolves Goonch Apr 8 #30
Make Kristi Noem a nice house dog. Emile Apr 8 #34
Give one to Trump! Old Testament Libera Apr 8 #36

Vogon_Glory

(9,772 posts)
2. If the ranchers who hate ordinary wolves have to start
Mon Apr 7, 2025, 04:55 PM
Apr 7

dealing with dire wolves, their howling will be dire!

Cirsium

(2,305 posts)
7. $10,000,000,000
Mon Apr 7, 2025, 05:23 PM
Apr 7

$10,000,000,000 capitalization for this sort of questionable commercial activity, but peanuts for programs to prevent extinction.

Cirsium

(2,305 posts)
33. I am so out of touch
Tue Apr 8, 2025, 12:58 PM
Apr 8

I saw "Free Willy" and thought it must be some recent pop culture reference, so I looked it up - hmm, 1993? Have I been disconnected from pop culture that long? Apparently it was a big success, do much so that anyone who is paying any attention at all should know about. Oh well. Jurassic Park - that I have heard of, because I read the Michael Crichton novel back in the day. I understand they made that into a film, so you are comparing and contrasting two films. Got it.

So, now that I have "done my research"... Yes! Jurassic Park vs Free Willy! Exactly.

Martin68

(25,425 posts)
31. It's always been a problem that only cute-looking adorable species get the attention needed. The twist here is that
Tue Apr 8, 2025, 12:38 PM
Apr 8

this is a wolf, not a cute little puppy dog.

LudwigPastorius

(12,180 posts)
16. Sure, it starts with cute little pups, but...
Mon Apr 7, 2025, 10:37 PM
Apr 7

ends with giant, previously extinct predators running amok in an orgy of blood, and the kicking, and the biting with the sharp teeth, and the hurting, and shoving.

PurgedVoter

(2,470 posts)
5. This is good
Mon Apr 7, 2025, 05:16 PM
Apr 7

dire /dīr/
adjective

Warning of or having dreadful or terrible consequences; calamitous.
"a dire economic forecast; dire threats."
Urgent; desperate.
"in dire need; dire poverty."
Ill-boding; portentous.
"dire omens"
Similar: ill-boding portentous

The American Heritage® Dictionary of the English Language, 5th Edition

Buzz cook

(2,702 posts)
10. Unfortunately Dire "wolves" weren't wolves.
Mon Apr 7, 2025, 06:59 PM
Apr 7

They got some DNA and found they weren't related.
https://www.scientificamerican.com/article/dire-wolves-were-not-really-wolves-new-genetic-clues-reveal/

"But a new study of dire wolf genetics has startled paleontologists: it found that these animals were not wolves at all, but rather the last of a dog lineage that evolved in North America."
"Dire wolves, it now appeared, had evolved in the Americas and had no close kinship with the gray wolves from Eurasia; the last time gray wolves and dire wolves shared a common ancestor was about 5.7 million years ago. The strong resemblance between the two, the researchers say, is a case of convergent evolution, "

Martin68

(25,425 posts)
32. Dire wolves werr not enormous wolves. According to Wikipedia they about the same size as the largest modern forms
Tue Apr 8, 2025, 12:43 PM
Apr 8

of gray wolf (Canis lupus), the Yukon wolf and the northwestern wolf. A. d. guildayi weighed on average 60 kilograms (132 lb) and A. d. dirus was on average 68 kg (150 lb). Its skull and dentition matched those of C. lupus, but its teeth were larger with greater shearing ability, and its bite force at the canine tooth was stronger than any known Canis species.

Response to Polybius (Original post)

OldBaldy1701E

(7,655 posts)
13. "... the dire wolf, a giant, extinct species made famous by the television series "Game of Thrones."
Mon Apr 7, 2025, 10:22 PM
Apr 7

And, all the D&D players snicker...

Brother Buzz

(38,300 posts)
17. Some of us were introduced to the Dire Wolf by Robert Hunter and the Gratful Dead
Mon Apr 7, 2025, 11:42 PM
Apr 7
Dire Wolf
Song by Grateful Dead ‧ 1970

In the timbers of Fennario
The wolves are runnin' 'round
The winter was so hard and cold
Froze ten feet 'neath the ground

Don't murder me
I beg of you, don't murder me
Please, don't murder me

I sat down to my supper
'Twas a bottle of red whisky
I said my prayers and went to bed
That's the last they saw of me

Don't murder me
I beg of you, don't murder me
Please, don't murder me

When I awoke, the dire wolf
600 pounds of sin
Was grinning at my window
All I said was, "Come on in"

Don't murder me
I beg of you, don't murder me
Please, don't murder me

The wolf came in, I got my cards
We sat down for a game
I cut my deck to the Queen of Spades
But the cards were all the same

Don't murder me
I beg of you, don't murder me
Please, don't murder me
Don't murder me

In the backwash of Fennario
The black and bloody mire
The dire wolf collects his due
While the boys sing 'round the fire

Don't murder me
I beg of you, don't murder me
Please, don't murder me

LudwigPastorius

(12,180 posts)
15. All I ask is that, if they are going to build a real life Jurassic Park,...
Mon Apr 7, 2025, 10:32 PM
Apr 7

do it somewhere near Mar-a-Lago.

LostOne4Ever

(9,645 posts)
20. They should have started with a species humans solely drove to extinction
Tue Apr 8, 2025, 03:20 AM
Apr 8

From what I am reading these wolves extinction probably wasn’t caused by humans alone.

Maybe a dodo bird or passenger pigeon?

Response to Polybius (Original post)

BidenRocks

(1,320 posts)
24. The La Brea Tar Pits
Tue Apr 8, 2025, 04:30 AM
Apr 8

I looked up Dire Wolf and found a reconstruction.
It will be interesting to see how close they got. Photo doesn't copy.
https://tarpits.org/stories/our-evolving-understanding-dire-wolves

Kablooie

(18,881 posts)
35. Canid DNA has been studied a lot.
Tue Apr 8, 2025, 07:18 PM
Apr 8

There is a lot of knowledge about dog and wolf DNA so they chose an extinct wolf as the first test of their technology.
They needed to prove that they could produce a healthy, viable animal.
In the future, they hope to resurrect the Dodo bird, Tasmanian Tiger, Mammoths and others.
They also plan to use the technology to help protect endangered species that exist today.

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